A novel role of NLRP3-generated IL-1β in the acute-chronic transition of peripheral lipopolysaccharide-elicited neuroinflammation: implications for sepsis-associated neurodegeneration

BACKGROUND: Sepsis-associated acute brain inflammation, if unresolved, may cause chronic neuroinflammation and resultant neurodegenerative diseases. However, little is known how the transition from acute to chronic neuroinflammation, which is critical for the following progressive neurodegeneration,...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Zhao, Zhan, Wang, Yubao, Zhou, Ran, Li, Yi, Gao, Yun, Tu, Dezhen, Wilson, Belinda, Song, Sheng, Feng, Jing, Hong, Jau-Shyong, Yakel, Jerrel L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7029475/
https://ncbi.nlm.nih.gov/pubmed/32070376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-1728-5
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