A novel role of NLRP3-generated IL-1β in the acute-chronic transition of peripheral lipopolysaccharide-elicited neuroinflammation: implications for sepsis-associated neurodegeneration

BACKGROUND: Sepsis-associated acute brain inflammation, if unresolved, may cause chronic neuroinflammation and resultant neurodegenerative diseases. However, little is known how the transition from acute to chronic neuroinflammation, which is critical for the following progressive neurodegeneration,...

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Détails bibliographiques
Publié dans:J Neuroinflammation
Auteurs principaux: Zhao, Zhan, Wang, Yubao, Zhou, Ran, Li, Yi, Gao, Yun, Tu, Dezhen, Wilson, Belinda, Song, Sheng, Feng, Jing, Hong, Jau-Shyong, Yakel, Jerrel L.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2020
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7029475/
https://ncbi.nlm.nih.gov/pubmed/32070376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-1728-5
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