A novel role of NLRP3-generated IL-1β in the acute-chronic transition of peripheral lipopolysaccharide-elicited neuroinflammation: implications for sepsis-associated neurodegeneration

BACKGROUND: Sepsis-associated acute brain inflammation, if unresolved, may cause chronic neuroinflammation and resultant neurodegenerative diseases. However, little is known how the transition from acute to chronic neuroinflammation, which is critical for the following progressive neurodegeneration,...

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Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Zhao, Zhan, Wang, Yubao, Zhou, Ran, Li, Yi, Gao, Yun, Tu, Dezhen, Wilson, Belinda, Song, Sheng, Feng, Jing, Hong, Jau-Shyong, Yakel, Jerrel L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7029475/
https://ncbi.nlm.nih.gov/pubmed/32070376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-1728-5
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