Genetic Diversity, Compartmentalization, and Age of HIV Proviruses Persisting in CD4(+) T Cell Subsets during Long-Term Combination Antiretroviral Therapy

The HIV reservoir, which comprises diverse proviruses integrated into the genomes of infected, primarily CD4(+) T cells, is the main barrier to developing an effective HIV cure. Our understanding of the genetics and dynamics of proviruses persisting within distinct CD4(+) T cell subsets, however, re...

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Publicado en:J Virol
Main Authors: Jones, Bradley R., Miller, Rachel L., Kinloch, Natalie N., Tsai, Olivia, Rigsby, Hawley, Sudderuddin, Hanwei, Shahid, Aniqa, Ganase, Bruce, Brumme, Chanson J., Harris, Marianne, Poon, Art F. Y., Brockman, Mark A., Fromentin, Rémi, Chomont, Nicolas, Joy, Jeffrey B., Brumme, Zabrina L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2020
Assuntos:
Genetic Diversity and Evolution
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022348/
https://ncbi.nlm.nih.gov/pubmed/31776273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01786-19
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