Longitudinal within-host evolution of HIV Nef-mediated CD4, HLA and SERINC5 downregulation activity: a case study

The HIV accessory protein Nef downregulates the viral entry receptor CD4, the Human Leukocyte Antigen (HLA)-A and -B molecules, the Serine incorporator 5 (SERINC5) protein and other molecules from the infected cell surface, thereby promoting viral infectivity, replication and immune evasion. The nef...

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Enregistré dans:
Détails bibliographiques
Publié dans:Retrovirology
Auteurs principaux: Sudderuddin, Hanwei, Kinloch, Natalie N., Jin, Steven W., Miller, Rachel L., Jones, Bradley R., Brumme, Chanson J., Joy, Jeffrey B., Brockman, Mark A., Brumme, Zabrina L.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2020
Sujets:
Short Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6953280/
https://ncbi.nlm.nih.gov/pubmed/31918727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-019-0510-1
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