Genetic Diversity, Compartmentalization, and Age of HIV Proviruses Persisting in CD4(+) T Cell Subsets during Long-Term Combination Antiretroviral Therapy

The HIV reservoir, which comprises diverse proviruses integrated into the genomes of infected, primarily CD4(+) T cells, is the main barrier to developing an effective HIV cure. Our understanding of the genetics and dynamics of proviruses persisting within distinct CD4(+) T cell subsets, however, re...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Jones, Bradley R., Miller, Rachel L., Kinloch, Natalie N., Tsai, Olivia, Rigsby, Hawley, Sudderuddin, Hanwei, Shahid, Aniqa, Ganase, Bruce, Brumme, Chanson J., Harris, Marianne, Poon, Art F. Y., Brockman, Mark A., Fromentin, Rémi, Chomont, Nicolas, Joy, Jeffrey B., Brumme, Zabrina L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Genetic Diversity and Evolution
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022348/
https://ncbi.nlm.nih.gov/pubmed/31776273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01786-19
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