Remethylation of Dnmt3a(−/−) hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing

Mutations in the DNA methyltransferase 3A (DNMT3A) gene are the most common cause of age-related clonal hematopoiesis (ARCH) in older individuals, and are among the most common initiating events for acute myeloid leukemia (AML). The most frequent DNMT3A mutation in AML patients (R882H) encodes a dom...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Ketkar, Shamika, Verdoni, Angela M., Smith, Amanda M., Bangert, Celia V., Leight, Elizabeth R., Chen, David Y., Brune, Meryl K., Helton, Nichole M., Hoock, Mieke, George, Daniel R., Fronick, Catrina, Fulton, Robert S., Ramakrishnan, Sai Mukund, Chang, Gue Su, Petti, Allegra A., Spencer, David H., Miller, Christopher A., Ley, Timothy J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022185/
https://ncbi.nlm.nih.gov/pubmed/31996479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1918611117
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