Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype

DNA hypomethylation is a feature of epidermal cells from aged and sun-exposed skin, but the mechanisms responsible for this methylation loss are not known. Dnmt3a is the dominant de novo DNA methyltransferase in the skin; while epidermal Dnmt3a deficiency creates a premalignant state in which kerati...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chen, David Y., Ferguson, Ian M., Braun, Krista A., Sutton, Leslie A., Helton, Nichole M., Ramakrishnan, Sai Mukund, Smith, Amanda M., Miller, Christopher A., Ley, Timothy J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8072215/
https://ncbi.nlm.nih.gov/pubmed/33846253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022760118
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