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Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome
Germline pathogenic variants in DNMT3A were recently described in patients with overgrowth, obesity, behavioral, and learning difficulties (DNMT3A Overgrowth Syndrome/DOS). Somatic mutations in the DNMT3A gene are also the most common cause of clonal hematopoiesis, and can initiate acute myeloid leu...
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| Udgivet i: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8316576/ https://ncbi.nlm.nih.gov/pubmed/34315901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24800-7 |
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