CpG island hypermethylation mediated by DNMT3A is a consequence of AML progression

DNMT3A mutations occur in ~25% of acute myeloid leukemia (AML) patients. The most common mutation, DNMT3A(R882H), has dominant negative activity that reduces DNA methylation activity by ~80% in vitro. To understand the contribution of DNMT3A-dependent methylation to leukemogenesis, we performed whol...

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Publié dans:Cell
Auteurs principaux: Spencer, David H., Russler-Germain, David A., Ketkar-Kulkarni, Shamika, Helton, Nichole M., Lamprecht, Tamara L., Fulton, Robert S., Fronick, Catrina C., O’Laughlin, Michelle, Heath, Sharon E., Shinawi, Marwan, Westervelt, Peter, Payton, Jacqueline E., Wartman, Lukas D., Welch, John S., Wilson, Richard K., Walter, Matthew J., Link, Daniel C., DiPersio, John F., Ley, Timothy J.
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328582/
https://ncbi.nlm.nih.gov/pubmed/28215704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.01.021
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