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CpG island hypermethylation mediated by DNMT3A is a consequence of AML progression
DNMT3A mutations occur in ~25% of acute myeloid leukemia (AML) patients. The most common mutation, DNMT3A(R882H), has dominant negative activity that reduces DNA methylation activity by ~80% in vitro. To understand the contribution of DNMT3A-dependent methylation to leukemogenesis, we performed whol...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Cell |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2017
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5328582/ https://ncbi.nlm.nih.gov/pubmed/28215704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.01.021 |
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