PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia

The DNA methyltransferases DNMT3A and DNMT3B are primarily responsible for de novo methylation of specific cytosine residues in CpG dinucleotides during mammalian development. While loss-of-function mutations in DNMT3A are highly recurrent in acute myeloid leukemia (AML), DNMT3A mutations are almost...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Cole, Christopher B., Verdoni, Angela M., Ketkar, Shamika, Leight, Elizabeth R., Russler-Germain, David A., Lamprecht, Tamara L., Demeter, Ryan T., Magrini, Vincent, Ley, Timothy J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701540/
https://ncbi.nlm.nih.gov/pubmed/26595813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI82897
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados