PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia

The DNA methyltransferases DNMT3A and DNMT3B are primarily responsible for de novo methylation of specific cytosine residues in CpG dinucleotides during mammalian development. While loss-of-function mutations in DNMT3A are highly recurrent in acute myeloid leukemia (AML), DNMT3A mutations are almost...

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Vydáno v:J Clin Invest
Hlavní autoři: Cole, Christopher B., Verdoni, Angela M., Ketkar, Shamika, Leight, Elizabeth R., Russler-Germain, David A., Lamprecht, Tamara L., Demeter, Ryan T., Magrini, Vincent, Ley, Timothy J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701540/
https://ncbi.nlm.nih.gov/pubmed/26595813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI82897
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