Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies

The gene that encodes de novo DNA methyltransferase 3A (DNMT3A) is frequently mutated in acute myeloid leukemia genomes. Point mutations at position R882 have been shown to cause a dominant negative loss of DNMT3A methylation activity, but 15% of DNMT3A mutations are predicted to produce truncated p...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Cole, Christopher B., Russler-Germain, David A., Ketkar, Shamika, Verdoni, Angela M., Smith, Amanda M., Bangert, Celia V., Helton, Nichole M., Guo, Mindy, Klco, Jeffery M., O’Laughlin, Shelly, Fronick, Catrina, Fulton, Robert, Chang, Gue Su, Petti, Allegra A., Miller, Christopher A., Ley, Timothy J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617681/
https://ncbi.nlm.nih.gov/pubmed/28872462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI93041
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