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Scalable Synthesis of a Key Intermediate for the Production of Pleuromutilin-Based Antibiotics
An improved synthesis of an eneimide, which is a useful precursor to pleuromutilin-based antibiotics, is reported. This synthesis proceeds in six steps and 17% overall yield (27% based on recovery of a key hydrindenone intermediate) and requires two fewer chromatography steps and five fewer days of...
Guardat en:
| Publicat a: | Org Lett |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7001007/ https://ncbi.nlm.nih.gov/pubmed/28858512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.7b02476 |
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