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Development of a Modular Synthetic Route to (+)-Pleuromutilin, (+)-12-epi-Mutilins, and Related Structures

We describe the development of an enantioselective synthetic route to (+)-pleuromutilin (1), (+)-12-epi-mutilin, and related derivatives. A key hydrindanone was prepared in three steps and 48% overall yield from cyclohex-2-en-1-one. 1,4-Hydrocyanation provided a nitrile (53%, or 85% based on recover...

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Publicat a:J Am Chem Soc
Autors principals: Zeng, Mingshuo, Murphy, Stephen K., Herzon, Seth B.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7024634/
https://ncbi.nlm.nih.gov/pubmed/29048164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b09869
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