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Scalable Synthesis of a Key Intermediate for the Production of Pleuromutilin-Based Antibiotics
An improved synthesis of an eneimide, which is a useful precursor to pleuromutilin-based antibiotics, is reported. This synthesis proceeds in six steps and 17% overall yield (27% based on recovery of a key hydrindenone intermediate) and requires two fewer chromatography steps and five fewer days of...
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| Udgivet i: | Org Lett |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7001007/ https://ncbi.nlm.nih.gov/pubmed/28858512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.7b02476 |
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