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Scalable Synthesis of a Key Intermediate for the Production of Pleuromutilin-Based Antibiotics

An improved synthesis of an eneimide, which is a useful precursor to pleuromutilin-based antibiotics, is reported. This synthesis proceeds in six steps and 17% overall yield (27% based on recovery of a key hydrindenone intermediate) and requires two fewer chromatography steps and five fewer days of...

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Publicado en:Org Lett
Autores principales: Murphy, Stephen K., Zeng, Mingshuo, Herzon, Seth B.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001007/
https://ncbi.nlm.nih.gov/pubmed/28858512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.7b02476
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