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A modular and enantioselective synthesis of the pleuromutilin antibiotics

The tricyclic diterpene fungal metabolite (+)-pleuromutilin has served as a starting point for antibiotic development. Semisynthetic modification of its glycolic acid subunit at C14 provided the first analogs fit for human use, and derivatization at C12 led to 12-epi-pleuromutilins with extended-spe...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Murphy, Stephen K., Zeng, Mingshuo, Herzon, Seth B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001679/
https://ncbi.nlm.nih.gov/pubmed/28572392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aan0003
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