טוען...
A modular and enantioselective synthesis of the pleuromutilin antibiotics
The tricyclic diterpene fungal metabolite (+)-pleuromutilin has served as a starting point for antibiotic development. Semisynthetic modification of its glycolic acid subunit at C14 provided the first analogs fit for human use, and derivatization at C12 led to 12-epi-pleuromutilins with extended-spe...
שמור ב:
| הוצא לאור ב: | Science |
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| Main Authors: | , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2017
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7001679/ https://ncbi.nlm.nih.gov/pubmed/28572392 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aan0003 |
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