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11-Step Enantioselective Synthesis of (−)-Lomaiviticin Aglycon

Lomaiviticins A and B are complex antitumor antibiotics that were isolated from a strain of Micromonospora. A confluence of several unusual structural features renders the lomaiviticins exceedingly challenging targets for chemical synthesis. We report an 11-step, enantioselective synthetic route to...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Herzon, Seth B., Lu, Liang, Woo, Christina M., Gholap, Shivajirao L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357143/
https://ncbi.nlm.nih.gov/pubmed/21280607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja200034b
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