Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNa(v)1.7

Pain is a significant public health burden in the United States, and current treatment approaches rely heavily on opioids, which often have limited efficacy and can lead to addiction. In humans, functional loss of the voltage-gated sodium channel Na(v)1.7 leads to pain insensitivity without deficits...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Neff, Robert A., Flinspach, Mack, Gibbs, Alan, Shih, Amy Y., Minassian, Natali A., Liu, Yi, Fellows, Ross, Libiger, Ondrej, Young, Stephanie, Pennington, Michael W., Hunter, Michael J., Wickenden, Alan D.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2020
Sujets:
Neurobiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996889/
https://ncbi.nlm.nih.gov/pubmed/31871053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011318
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