Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNa(v)1.7

Pain is a significant public health burden in the United States, and current treatment approaches rely heavily on opioids, which often have limited efficacy and can lead to addiction. In humans, functional loss of the voltage-gated sodium channel Na(v)1.7 leads to pain insensitivity without deficits...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Neff, Robert A., Flinspach, Mack, Gibbs, Alan, Shih, Amy Y., Minassian, Natali A., Liu, Yi, Fellows, Ross, Libiger, Ondrej, Young, Stephanie, Pennington, Michael W., Hunter, Michael J., Wickenden, Alan D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996889/
https://ncbi.nlm.nih.gov/pubmed/31871053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011318
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