Tarantula Huwentoxin-IV Inhibits Neuronal Sodium Channels by Binding to Receptor Site 4 and Trapping the Domain II Voltage Sensor in the Closed Configuration

Peptide toxins with high affinity, divergent pharmacological functions, and isoform-specific selectivity are powerful tools for investigating the structure-function relationships of voltage-gated sodium channels (VGSCs). Although a number of interesting inhibitors have been reported from tarantula v...

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Detalhes bibliográficos
Main Authors: Xiao, Yucheng, Bingham, Jon-Paul, Zhu, Weiguo, Moczydlowski, Edward, Liang, Songping, Cummins, Theodore R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Membrane Transport, Structure, Function, and Biogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556013/
https://ncbi.nlm.nih.gov/pubmed/18628201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708447200
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