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The Tarantula Toxins ProTx-II and Huwentoxin-IV Differentially Interact with Human Na(v)1.7 Voltage Sensors to Inhibit Channel Activation and Inactivation

The voltage-gated sodium channel Na(v)1.7 plays a crucial role in pain, and drugs that inhibit hNa(v)1.7 may have tremendous therapeutic potential. ProTx-II and huwentoxin-IV (HWTX-IV), cystine knot peptides from tarantula venoms, preferentially block hNa(v)1.7. Understanding the interactions of the...

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Detalhes bibliográficos
Main Authors: Xiao, Yucheng, Blumenthal, Kenneth, Jackson, James O., Liang, Songping, Cummins, Theodore R.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993464/
https://ncbi.nlm.nih.gov/pubmed/20855463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.066332
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