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The Tarantula Toxins ProTx-II and Huwentoxin-IV Differentially Interact with Human Na(v)1.7 Voltage Sensors to Inhibit Channel Activation and Inactivation
The voltage-gated sodium channel Na(v)1.7 plays a crucial role in pain, and drugs that inhibit hNa(v)1.7 may have tremendous therapeutic potential. ProTx-II and huwentoxin-IV (HWTX-IV), cystine knot peptides from tarantula venoms, preferentially block hNa(v)1.7. Understanding the interactions of the...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The American Society for Pharmacology and Experimental
Therapeutics
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2993464/ https://ncbi.nlm.nih.gov/pubmed/20855463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.066332 |
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