Common Molecular Determinants of Tarantula Huwentoxin-IV Inhibition of Na(+) Channel Voltage Sensors in Domains II and IV

The voltage sensors of domains II and IV of sodium channels are important determinants of activation and inactivation, respectively. Animal toxins that alter electrophysiological excitability of muscles and neurons often modify sodium channel activation by selectively interacting with domain II and...

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Autores principales: Xiao, Yucheng, Jackson, James O., Liang, Songping, Cummins, Theodore R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Neurobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149324/
https://ncbi.nlm.nih.gov/pubmed/21659528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.246876
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