Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV (μ-TRTX-Hh2a)

Voltage-gated sodium channels (VGSCs) are essential to the normal function of the vertebrate nervous system. Aberrant function of VGSCs underlies a variety of disorders, including epilepsy, arrhythmia, and pain. A large number of animal toxins target these ion channels and may have significant thera...

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Bibliografski detalji
Glavni autori: Minassian, Natali A., Gibbs, Alan, Shih, Amy Y., Liu, Yi, Neff, Robert A., Sutton, Steven W., Mirzadegan, Tara, Connor, Judith, Fellows, Ross, Husovsky, Matthew, Nelson, Serena, Hunter, Michael J., Flinspach, Mack, Wickenden, Alan D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Neurobiology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829356/
https://ncbi.nlm.nih.gov/pubmed/23760503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.461392
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