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Modulatory features of the novel spider toxin μ‐TRTX‐Df1a isolated from the venom of the spider Davus fasciatus

BACKGROUND AND PURPOSE: Naturally occurring dysfunction of voltage‐gated sodium (Na(V)) channels results in complex disorders such as chronic pain, making these channels an attractive target for new therapies. In the pursuit of novel Na(V) modulators, we investigated spider venoms for new inhibitors...

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Библиографические подробности
Опубликовано в: :Br J Pharmacol
Главные авторы: Cardoso, Fernanda C, Dekan, Zoltan, Smith, Jennifer J, Deuis, Jennifer R, Vetter, Irina, Herzig, Volker, Alewood, Paul F, King, Glenn F, Lewis, Richard J
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5513869/
https://ncbi.nlm.nih.gov/pubmed/28542706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13865
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