Modulatory features of the novel spider toxin μ‐TRTX‐Df1a isolated from the venom of the spider Davus fasciatus

BACKGROUND AND PURPOSE: Naturally occurring dysfunction of voltage‐gated sodium (Na(V)) channels results in complex disorders such as chronic pain, making these channels an attractive target for new therapies. In the pursuit of novel Na(V) modulators, we investigated spider venoms for new inhibitors...

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Bibliographische Detailangaben
Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Cardoso, Fernanda C, Dekan, Zoltan, Smith, Jennifer J, Deuis, Jennifer R, Vetter, Irina, Herzig, Volker, Alewood, Paul F, King, Glenn F, Lewis, Richard J
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5513869/
https://ncbi.nlm.nih.gov/pubmed/28542706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13865
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