Pharmacological characterisation of the highly Na(V)1.7 selective spider venom peptide Pn3a

Human genetic studies have implicated the voltage-gated sodium channel Na(V)1.7 as a therapeutic target for the treatment of pain. A novel peptide, μ-theraphotoxin-Pn3a, isolated from venom of the tarantula Pamphobeteus nigricolor, potently inhibits Na(V)1.7 (IC(50) 0.9 nM) with at least 40–1000-fol...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Deuis, Jennifer R., Dekan, Zoltan, Wingerd, Joshua S., Smith, Jennifer J., Munasinghe, Nehan R., Bhola, Rebecca F., Imlach, Wendy L., Herzig, Volker, Armstrong, David A., Rosengren, K. Johan, Bosmans, Frank, Waxman, Stephen G., Dib-Hajj, Sulayman D., Escoubas, Pierre, Minett, Michael S., Christie, Macdonald J., King, Glenn F., Alewood, Paul F., Lewis, Richard J., Wood, John N., Vetter, Irina
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247677/
https://ncbi.nlm.nih.gov/pubmed/28106092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40883
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg