Addition of K22 Converts Spider Venom Peptide Pme2a from an Activator to an Inhibitor of Na<sub>V</sub>1.7

Spider venom is a novel source of disulfide-rich peptides with potent and selective activity at voltage-gated sodium channels (Na<sub>V</sub>). Here, we describe the discovery of &#956;-theraphotoxin-Pme1a and &#956;/<i>&#948;</i>-theraphotoxin-Pme2a, two novel pe...

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Main Authors: Kathleen Yin, Jennifer R. Deuis, Zoltan Dekan, Ai-Hua Jin, Paul F. Alewood, Glenn F. King, Volker Herzig, Irina Vetter
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-02-01
Colecção:Biomedicines
Assuntos:
sodium channel
na<sub>v</sub>1.7
na<sub>v</sub>1.8
venom
spider
peptide
Acesso em linha:https://www.mdpi.com/2227-9059/8/2/37
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