Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV (μ-TRTX-Hh2a)

Voltage-gated sodium channels (VGSCs) are essential to the normal function of the vertebrate nervous system. Aberrant function of VGSCs underlies a variety of disorders, including epilepsy, arrhythmia, and pain. A large number of animal toxins target these ion channels and may have significant thera...

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Autori principali: Minassian, Natali A., Gibbs, Alan, Shih, Amy Y., Liu, Yi, Neff, Robert A., Sutton, Steven W., Mirzadegan, Tara, Connor, Judith, Fellows, Ross, Husovsky, Matthew, Nelson, Serena, Hunter, Michael J., Flinspach, Mack, Wickenden, Alan D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Neurobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829356/
https://ncbi.nlm.nih.gov/pubmed/23760503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.461392
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