Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNa(v)1.7

Pain is a significant public health burden in the United States, and current treatment approaches rely heavily on opioids, which often have limited efficacy and can lead to addiction. In humans, functional loss of the voltage-gated sodium channel Na(v)1.7 leads to pain insensitivity without deficits...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Neff, Robert A., Flinspach, Mack, Gibbs, Alan, Shih, Amy Y., Minassian, Natali A., Liu, Yi, Fellows, Ross, Libiger, Ondrej, Young, Stephanie, Pennington, Michael W., Hunter, Michael J., Wickenden, Alan D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2020
Gaiak:
Neurobiology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996889/
https://ncbi.nlm.nih.gov/pubmed/31871053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011318
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak