Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNa(v)1.7

Pain is a significant public health burden in the United States, and current treatment approaches rely heavily on opioids, which often have limited efficacy and can lead to addiction. In humans, functional loss of the voltage-gated sodium channel Na(v)1.7 leads to pain insensitivity without deficits...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Biol Chem
Κύριοι συγγραφείς: Neff, Robert A., Flinspach, Mack, Gibbs, Alan, Shih, Amy Y., Minassian, Natali A., Liu, Yi, Fellows, Ross, Libiger, Ondrej, Young, Stephanie, Pennington, Michael W., Hunter, Michael J., Wickenden, Alan D.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Biochemistry and Molecular Biology 2020
Θέματα:
Neurobiology
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996889/
https://ncbi.nlm.nih.gov/pubmed/31871053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011318
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