The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Na(v)1.7

[Image: see text] Spider venom toxins, such as Protoxin-II (ProTx-II), have recently received much attention as selective Na(v)1.7 channel blockers, with potential to be developed as leads for the treatment of chronic nocioceptive pain. ProTx-II is a 30-amino acid peptide with three disulfide bonds...

Szczegółowa specyfikacja

Zapisane w:
Opis bibliograficzny
Wydane w:J Am Chem Soc
Główni autorzy: Wright, Zoë V. F., McCarthy, Stephen, Dickman, Rachael, Reyes, Francis E., Sanchez-Martinez, Silvia, Cryar, Adam, Kilford, Ian, Hall, Adrian, Takle, Andrew K., Topf, Maya, Gonen, Tamir, Thalassinos, Konstantinos, Tabor, Alethea B.
Format: Artigo
Język:Inglês
Wydane: American Chemical Society 2017
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5618157/
https://ncbi.nlm.nih.gov/pubmed/28880078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b06506
Etykiety: Dodaj etykietę
Nie ma etykietki, Dołącz pierwszą etykiete!

Podobne zapisy