Large deletions in immunoglobulin genes are associated with a sustained absence of DNA Polymerase η

Somatic hypermutation of immunoglobulin genes is a highly mutagenic process that is B cell-specific and occurs during antigen-driven responses leading to antigen specificity and antibody affinity maturation. Mutations at the Ig locus are initiated by Activation-Induced cytidine Deaminase and are equ...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Lerner, Leticia K., Nguyen, Thuy V., Castro, Ligia P., Vilar, Juliana B., Munford, Veridiana, Le Guillou, Morwenna, Mohammad, Mahwish Mian, Vergé, Véronique, Rosselli, Filippo, Menck, Carlos F. M., Sarasin, Alain, Aoufouchi, Said
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2020
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6987143/
https://ncbi.nlm.nih.gov/pubmed/31992747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58180-7
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