Contribution of DNA polymerase η to immunoglobulin gene hypermutation in the mouse

The mutation pattern of immunoglobulin genes was studied in mice deficient for DNA polymerase η, a translesional polymerase whose inactivation is responsible for the xeroderma pigmentosum variant (XP-V) syndrome in humans. Mutations show an 85% G/C biased pattern, similar to that reported for XP-V p...

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Bibliografiske detaljer
Main Authors: Delbos, Frédéric, De Smet, Annie, Faili, Ahmad, Aoufouchi, Said, Weill, Jean-Claude, Reynaud, Claude-Agnès
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2005
Fag:
Brief Definitive Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213152/
https://ncbi.nlm.nih.gov/pubmed/15824086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050292
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