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Contribution of DNA polymerase η to immunoglobulin gene hypermutation in the mouse
The mutation pattern of immunoglobulin genes was studied in mice deficient for DNA polymerase η, a translesional polymerase whose inactivation is responsible for the xeroderma pigmentosum variant (XP-V) syndrome in humans. Mutations show an 85% G/C biased pattern, similar to that reported for XP-V p...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2213152/ https://ncbi.nlm.nih.gov/pubmed/15824086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050292 |
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