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DNA polymerase η is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse

Mutations at A/T bases within immunoglobulin genes have been shown to be generated by a repair pathway involving the DNA-binding moiety of the mismatch repair complex constituted by the MSH2–MSH6 proteins, together with DNA polymerase η (pol η). However, residual A/T mutagenesis is still observed up...

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Dettagli Bibliografici
Autori principali: Delbos, Frédéric, Aoufouchi, Said, Faili, Ahmad, Weill, Jean-Claude, Reynaud, Claude-Agnès
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118439/
https://ncbi.nlm.nih.gov/pubmed/17190840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062131
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