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DNA Polymerase η Is Involved in Hypermutation Occurring during Immunoglobulin Class Switch Recombination
Base substitutions, deletions, and duplications are observed at the immunoglobulin locus in DNA sequences involved in class switch recombination (CSR). These mutations are dependent upon activation-induced cytidine deaminase (AID) and present all the characteristics of the ones observed during V gen...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2211761/ https://ncbi.nlm.nih.gov/pubmed/14734526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20031831 |
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