Transcription, beta-like DNA polymerases and hypermutation.

This paper discusses two aspects of immunoglobulin (Ig) gene hypermutation. In the first approach, a transcription termination signal is introduced in an Ig light chain transgene acting as a mutation substrate, and transgenic lines are generated with control and mutant transgenes integrated in tande...

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Main Authors: Reynaud, C A, Frey, S, Aoufouchi, S, Faili, A, Bertocci, B, Dahan, A, Flatter, E, Delbos, F, Storck, S, Zober, C, Weill, J C
Format: Artigo
Sprog:Inglês
Udgivet: 2001
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087696/
https://ncbi.nlm.nih.gov/pubmed/11205336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2000.0753
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