Large deletions in immunoglobulin genes are associated with a sustained absence of DNA Polymerase η

Somatic hypermutation of immunoglobulin genes is a highly mutagenic process that is B cell-specific and occurs during antigen-driven responses leading to antigen specificity and antibody affinity maturation. Mutations at the Ig locus are initiated by Activation-Induced cytidine Deaminase and are equ...

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Publicado no:Sci Rep
Main Authors: Lerner, Leticia K., Nguyen, Thuy V., Castro, Ligia P., Vilar, Juliana B., Munford, Veridiana, Le Guillou, Morwenna, Mohammad, Mahwish Mian, Vergé, Véronique, Rosselli, Filippo, Menck, Carlos F. M., Sarasin, Alain, Aoufouchi, Said
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6987143/
https://ncbi.nlm.nih.gov/pubmed/31992747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58180-7
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