Large deletions in immunoglobulin genes are associated with a sustained absence of DNA Polymerase η

Somatic hypermutation of immunoglobulin genes is a highly mutagenic process that is B cell-specific and occurs during antigen-driven responses leading to antigen specificity and antibody affinity maturation. Mutations at the Ig locus are initiated by Activation-Induced cytidine Deaminase and are equ...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Lerner, Leticia K., Nguyen, Thuy V., Castro, Ligia P., Vilar, Juliana B., Munford, Veridiana, Le Guillou, Morwenna, Mohammad, Mahwish Mian, Vergé, Véronique, Rosselli, Filippo, Menck, Carlos F. M., Sarasin, Alain, Aoufouchi, Said
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6987143/
https://ncbi.nlm.nih.gov/pubmed/31992747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58180-7
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