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V(D)J recombination process and the Pre-B to immature B-cells transition are altered in Fanca(−/−) mice
B-lymphocytes in the bone marrow (BM) must generate a functional B-cell receptor and overcome the negative selection induced by reactivity with autoantigens. Two rounds of DNA recombination are required for the production of functional immunoglobulin heavy (Ig-HCs) and light (LCs) chains necessary f...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5121645/ https://ncbi.nlm.nih.gov/pubmed/27883081 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36906 |
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