Defective endomitosis during megakaryopoiesis leads to thrombocytopenia in Fanca(−/−) mice

Fanconi anemia (FA) is an inherited chromosomal instability syndrome that is characterized by progressive bone marrow failure. One of the main causes of morbidity and mortality in FA is a bleeding tendency, resulting from low platelet counts. Platelets are the final products of megakaryocyte (MK) ma...

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Bibliographische Detailangaben
Veröffentlicht in:Blood
Hauptverfasser: Pawlikowska, Patrycja, Fouchet, Pierre, Vainchenker, William, Rosselli, Filippo, Naim, Valeria
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2014
Schlagworte:
Platelets and Thrombopoiesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256912/
https://ncbi.nlm.nih.gov/pubmed/25261197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-01-551457
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