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Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization
Megakaryocyte maturation and polyploidization are critical for platelet production; abnormalities in these processes are associated with myeloproliferative disorders, including thrombocytopenia. Megakaryocyte maturation signals through cascades that involve p21-activated kinase (Pak) function; howev...
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| 發表在: | Blood |
|---|---|
| Main Authors: | , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society of Hematology
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4424419/ https://ncbi.nlm.nih.gov/pubmed/25824689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-10-604504 |
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