Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization

Megakaryocyte maturation and polyploidization are critical for platelet production; abnormalities in these processes are associated with myeloproliferative disorders, including thrombocytopenia. Megakaryocyte maturation signals through cascades that involve p21-activated kinase (Pak) function; howev...

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Publicado en:Blood
Autores principales: Kosoff, Rachelle E., Aslan, Joseph E., Kostyak, John C., Dulaimi, Essel, Chow, Hoi Yee, Prudnikova, Tatiana Y., Radu, Maria, Kunapuli, Satya P., McCarty, Owen J. T., Chernoff, Jonathan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2015
Materias:
Platelets and Thrombopoiesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424419/
https://ncbi.nlm.nih.gov/pubmed/25824689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-10-604504
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