Defective regulatory B-cell compartment in patients with immune thrombocytopenia

B lymphocytes producing antiplatelet autoantibodies play a major role in autoimmune thrombocytopenia (ITP). However, certain B cells, including the human CD19(+)CD24(hi)CD38(hi) subpopulation, possess regulatory functions mediated partly by IL-10. In a cohort of chronic ITP patients with low platele...

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Hlavní autoři: Li, Xiaojuan, Zhong, Hui, Bao, Weili, Boulad, Nayla, Evangelista, Jessie, Haider, Muhammad Anis, Bussel, James, Yazdanbakhsh, Karina
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2012
Témata:
Platelets and Thrombopoiesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476542/
https://ncbi.nlm.nih.gov/pubmed/22859611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-05-432575
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