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129-Derived Mouse Strains Express an Unstable but Catalytically Active DNA Polymerase Iota Variant

Mice derived from the 129 strain have a nonsense codon mutation in exon 2 of the polymerase iota (Polι) gene and are therefore considered Polι deficient. When we amplified Polι mRNA from 129/SvJ or 129/Ola testes, only a small fraction of the full-length cDNA contained the nonsense mutation; the maj...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Aoufouchi, Said, De Smet, Annie, Delbos, Frédéric, Gelot, Camille, Guerrera, Ida Chiara, Weill, Jean-Claude, Reynaud, Claude-Agnès
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4525304/
https://ncbi.nlm.nih.gov/pubmed/26124279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00371-15
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