MeCP2 represses the rate of transcriptional initiation of highly methylated long genes

Mutations in the methyl-DNA-binding repressor protein MeCP2 cause the devastating neurodevelopmental disorder Rett syndrome. It has been challenging to understand how MeCP2 regulates transcription because MeCP2 binds broadly across the genome, and MeCP2 mutations are associated with widespread small...

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Bibliografske podrobnosti
izdano v:Mol Cell
Main Authors: Boxer, Lisa D., Renthal, William, Greben, Alexander W., Whitwam, Tess, Silberfeld, Andrew, Stroud, Hume, Li, Emmy, Yang, Marty G., Kinde, Benyam, Griffith, Eric C., Bonev, Boyan, Greenberg, Michael E.
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6982532/
https://ncbi.nlm.nih.gov/pubmed/31784358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.10.032
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