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MeCP2 represses enhancers through chromosome topology-associated DNA methylation

The genomes of mammalian neurons contain uniquely high levels of non-CG DNA methylation that can be bound by the Rett syndrome protein, MeCP2, to regulate gene expression. How patterns of non-CG methylation are established in neurons and the mechanism by which this methylation works with MeCP2 to co...

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Publicat a:Mol Cell
Autors principals: Clemens, Adam W., Wu, Dennis Y., Moore, J. Russell, Christian, Diana L., Zhao, Guoyan, Gabel, Harrison W.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980697/
https://ncbi.nlm.nih.gov/pubmed/31784360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.10.033
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