MeCP2 represses the rate of transcriptional initiation of highly methylated long genes

Mutations in the methyl-DNA-binding repressor protein MeCP2 cause the devastating neurodevelopmental disorder Rett syndrome. It has been challenging to understand how MeCP2 regulates transcription because MeCP2 binds broadly across the genome, and MeCP2 mutations are associated with widespread small...

詳細記述

保存先:
書誌詳細
出版年:Mol Cell
主要な著者: Boxer, Lisa D., Renthal, William, Greben, Alexander W., Whitwam, Tess, Silberfeld, Andrew, Stroud, Hume, Li, Emmy, Yang, Marty G., Kinde, Benyam, Griffith, Eric C., Bonev, Boyan, Greenberg, Michael E.
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6982532/
https://ncbi.nlm.nih.gov/pubmed/31784358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.10.032
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