लोड हो रहा है...
Direct targeting of oncogenic RAS mutants with a tumor-specific cytosol-penetrating antibody inhibits RAS mutant–driven tumor growth
Oncogenic RAS mutant (RAS(MUT)) proteins have been considered undruggable via conventional antibody regimens owing to the intracellular location restricting conventional-antibody accessibility. Here, we report a pan-RAS–targeting IgG antibody, inRas37, which directly targets the intracellularly acti...
में बचाया:
| में प्रकाशित: | Sci Adv |
|---|---|
| मुख्य लेखकों: | , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
American Association for the Advancement of Science
2020
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6962039/ https://ncbi.nlm.nih.gov/pubmed/31998840 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay2174 |
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