Anti-helminthic niclosamide inhibits Ras-driven oncogenic transformation via activation of GSK-3

Despite the importance of Ras oncogenes as a therapeutic target in human cancer, their ‘undruggable’ tertiary structures limit the effectiveness of anti-Ras drugs. Canonical Wnt signaling contributes to Ras activity by glycogen synthase kinase 3 (GSK-3)-dependent phosphorylation at the C-terminus an...

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Udgivet i:Oncotarget
Main Authors: Ahn, Sung Yong, Yang, Ji Hye, Kim, Nam Hee, Lee, Kyungro, Cha, Yong Hoon, Yun, Jun Seop, Kang, Hee Eun, Lee, Yoonmi, Choi, Jiwon, Kim, Hyun Sil, Yook, Jong In
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458253/
https://ncbi.nlm.nih.gov/pubmed/28418865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16255
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