Anti-helminthic niclosamide inhibits Ras-driven oncogenic transformation via activation of GSK-3

Despite the importance of Ras oncogenes as a therapeutic target in human cancer, their ‘undruggable’ tertiary structures limit the effectiveness of anti-Ras drugs. Canonical Wnt signaling contributes to Ras activity by glycogen synthase kinase 3 (GSK-3)-dependent phosphorylation at the C-terminus an...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Ahn, Sung Yong, Yang, Ji Hye, Kim, Nam Hee, Lee, Kyungro, Cha, Yong Hoon, Yun, Jun Seop, Kang, Hee Eun, Lee, Yoonmi, Choi, Jiwon, Kim, Hyun Sil, Yook, Jong In
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2017
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458253/
https://ncbi.nlm.nih.gov/pubmed/28418865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16255
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki